The Macrocyclic Effect ·
Why Ring-Shaped Ligands Outbind Their Open-Chain Cousins
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.com · cyclam · Cu²⁺ · preorganization
ligand
—
log K
—
ΔΔG
—
step
—
Cu²⁺ metal ion
cyclam (macrocycle)
2,3,2-tet (open chain)
N donor lone pairs
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.com · Macrocyclic Effect
Un
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.com · The Macrocyclic Effect — Concepts